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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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Tos-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds consist of two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting the protein intended for degradation. PROTACs leverage the intracellular ubiquitin-proteasome system for selective protein degradation.
PEG-based PROTAC linker
Utilized in the synthesis of PROTACs
Molecular weight: 476.58
Chemical formula: C22H36O9S
Appears as a viscous liquid
Colorless to light yellow
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Trimethoxy(4-phenylbutyl)silane is a versatile drug intermediate used in the synthesis of various active compounds. This chemical is stable under recommended storage conditions, ensuring product integrity over time.
Stable under recommended storage conditions
Used for synthesizing active compounds
Suitable for laboratory chemicals and manufacturing
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N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG derivative that contains an amino group and two terminal carboxylic acids. The amino group is reactive with carboxylic acids and activated NHS esters. The terminal carboxylic acids can react with primary amine groups in the presence of activators to form a stable amide bond. This compound is useful in the development of antibody drug conjugates (ADCs).
Contains an amino group and two terminal carboxylic acids
Amino group is reactive with carboxylic acids and activated NHS esters
Terminal carboxylic acids can react with primary amine groups
Forms a stable amide bond
Useful in the development of antibody drug conjugates (ADCs)
For research use only
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OSI-420 free base (CAS 183321-86-0) is an active metabolite of erlotinib (OSI-774) exhibiting inhibitory activity against epidermal growth factor receptor (EGFR) tyrosine kinase Mechanistically OSI-420 inhibits EGFR by binding competitively to the ATP-binding site within the intracellular kinase domain thus preventing receptor autophosphorylation and subsequent signaling Additionally through EGFR inhibition it can trigger apoptosis via mitochondrial disruption including loss of mitochondrial membrane potential and cytochrome c release OSI-420 is utilized in biomedical research for studying EGFR-related signaling pathways and apoptosis mechanisms
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